Nitric oxide synthase 2 (inducible)

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PDB 1nsi EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Aliases NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Genetically Related Diseases
Targeted by Drug
pimagedine, nitroarginine, 2-amino-4-methylpyridine[2]
RNA expression pattern
PBB GE NOS2A 210037 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 17: 27.76 – 27.8 Mb Chr 11: 78.92 – 78.96 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.[5]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]


Nitric oxide synthase 2A has been shown to interact with Caveolin 1[7] and Rac2.[8]


  1. ^ "Diseases that are genetically associated with NOS2 view/edit references on wikidata". 
  2. ^ "Drugs that physically interact with Nitric oxide synthase 2 view/edit references on wikidata". 
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA. 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326Freely accessible. PMID 7682706. 
  6. ^ "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)". 
  7. ^ Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919Freely accessible. PMID 11114180. 
  8. ^ Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.