Nitric oxide synthase 2 (inducible)

NOS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS
Identifiers
Aliases	NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2
External IDs	OMIM: 163730 MGI: 97361 HomoloGene: 55473 GeneCards: NOS2
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 27,756,766 bp End 27,800,529 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B5|11 46.74 cM Start 78,811,613 bp End 78,851,080 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum appendix prefrontal cortex duodenum Brodmann area 9 cingulate gyrus upper lobe of left lung right lung ganglionic eminence smooth muscle tissue Top expressed in jejunum placenta thymus entorhinal cortex skeletal muscle tissue esophagus neural tube adrenal gland lens stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FMN binding protein homodimerization activity flavin adenine dinucleotide binding arginine binding tetrahydrobiopterin binding metal ion binding calmodulin binding protein binding heme binding oxidoreductase activity signaling receptor binding nitric-oxide synthase activity NADPH-hemoprotein reductase activity NADP binding Cellular component cytoplasm cytosol cortical cytoskeleton peroxisome intracellular anatomical structure perinuclear region of cytoplasm nucleus peroxisomal matrix plasma membrane vesicle membrane Biological process positive regulation of guanylate cyclase activity response to hypoxia nitric oxide biosynthetic process positive regulation of leukocyte mediated cytotoxicity response to bacterium negative regulation of protein catabolic process regulation of insulin secretion negative regulation of blood pressure regulation of cytokine production involved in inflammatory response positive regulation of killing of cells of other organism negative regulation of gene expression cell redox homeostasis arginine catabolic process prostaglandin secretion response to lipopolysaccharide innate immune response in mucosa regulation of cell population proliferation peptidyl-cysteine S-nitrosylation defense response to bacterium circadian rhythm defense response to Gram-negative bacterium nitric oxide mediated signal transduction cellular response to interferon-gamma regulation of cellular respiration cellular response to lipopolysaccharide superoxide metabolic process cytokine-mediated signaling pathway protein targeting to peroxisome response to hormone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4843 18126 Ensembl ENSG00000007171 ENSMUSG00000020826 UniProt P35228 P29477 RefSeq (mRNA) NM_000625 NM_153292 NM_010927 NM_001313921 NM_001313922 RefSeq (protein) NP_000616 NP_001300850 NP_001300851 NP_035057 Location (UCSC) Chr 17: 27.76 – 27.8 Mb Chr 11: 78.81 – 78.85 Mb PubMed search
Wikidata
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Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1 and Rac2.