Related to receptor tyrosine kinase

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Aliases RYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase
External IDs OMIM: 600524 MGI: 101766 HomoloGene: 68287 GeneCards: RYK
Gene location (Human)
Chromosome 3 (human)
Chr. Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for RYK
Genomic location for RYK
Band 3q22.2 Start 134,065,303 bp[1]
End 134,250,744 bp[1]
RNA expression pattern
PBB GE RYK 202853 s at fs.png

PBB GE RYK 216976 s at fs.png

PBB GE RYK 214172 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 134.07 – 134.25 Mb Chr 3: 102.83 – 102.91 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk. The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.[5]


The gene encoding mouse RYK was first identified in 1992.[6] Subsequently, cDNA encoding the RYK protein have been isolated from the following species.[7]


In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal domain, an extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.[7]


RYK is involved in regulation of axon growth during development of the nervous system.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163785 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032547 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: RYK RYK receptor-like tyrosine kinase". 
  6. ^ Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs". Proc. Natl. Acad. Sci. USA. 89 (24): 11818–11822. PMC 50648Freely accessible. PMID 1334548. doi:10.1073/pnas.89.24.11818. 
  7. ^ a b Halford, MM; Stacker, S.A. (2001). "Revelations of the RYK receptor". BioEssays. 23 (1): 34–45. PMID 11135307. doi:10.1002/1521-1878(200101)23:1<34::AID-BIES1005>3.0.CO;2-D. 
  8. ^ Edmund R Hollis, Nao Ishiko, Ting Yu, Chin-Chun Lu, Ariela Haimovich, Kristine Tolentino, Alisha Richman, Anna Tury, Shih-Hsiu Wang, Maysam Pessian, Euna Jo, Alex Kolodkin, Yimin Zou. Ryk controls remapping of motor cortex during functional recovery after spinal cord injury. Nature Neuroscience 2016; doi: 10.1038/nn.4282

Further reading[edit]