Lilotomab

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Lilotomab
Monoclonal antibody
Type Whole antibody
Source Mouse
Target CD37
Clinical data
Synonyms Tetulomab, HH1
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none

Lilotomab (formerly tetulomab, HH1)[1] is a murine monoclonal antibody against CD37,[2] a glycoprotein which is expressed on the surface of mature human B cells.[3] It was generated at the Norwegian Radium Hospital.[3]

As of 2016 it was under development by the Norwegian company Nordic Nanovector ASA as a radioimmunotherapeutic in which lilotomab is conjugated to the beta radiation-emitting isotope lutetium-177 by means of a linker called satetraxetan, a derivative of DOTA.[2] This compound is called 177Lu-HH1 or lutetium (177Lu) lilotomab satetraxetan (trade name Betalutin).[1] As of 2016, a phase 1/2 clinical trial in people with non-Hodgkin lymphoma was underway.[4]

The satetraxetan structure chelating lutetium-177[5]

References[edit]

  1. ^ a b "Lutetium (177lu) lilotomab satetraxetan". Adis Insight. Retrieved 1 September 2016. 
  2. ^ a b "Recommended INN List 74" (PDF). WHO Drug Information. 29 (3). 2015. 
  3. ^ a b Robak T, Robak P (2014). "Anti-CD37 antibodies for chronic lymphocytic leukemia". Expert Opin Biol Ther. 14 (5): 651–61. doi:10.1517/14712598.2014.890182. PMID 24555705. 
  4. ^ "EudraCT Number: 2011-000033-36". EU Clinical Trials Registry. Treatment of lymphoma with targeted internal radiation therapy (Betalutin) 
  5. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 112" (PDF). WHO Drug Information. 28 (4): 515. 2014. 

Further reading[edit]