UGT1A4

UGT1A4
Identifiers
Aliases	UGT1A4, HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D, UGT1A4S, UDP glucuronosyltransferase family 1 member A4, UGT1-01, UGT-1A, UGT1A, hUG-BR1, UGT1, GNT1, UGT1.1, UGT1A1
External IDs	OMIM: 606429; MGI: 3032634; HomoloGene: 88621; GeneCards: UGT1A4; OMA:UGT1A4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	233,773,300 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	88,146,719 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; gallbladder; ; mucosa of transverse colon; ; human kidney; ; olfactory zone of nasal mucosa; ; urinary bladder; ; mucosa of esophagus; ; renal cortex; ; zone of skin;
	Top expressed in
	hepatobiliary system; ; liver; ; granulocyte; ; urinary bladder; ; uterus; ; mouth; ; lip; ; spleen; ; colon; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; retinoic acid binding; hexosyltransferase activity; protein homodimerization activity; glycosyltransferase activity; protein heterodimerization activity; enzyme binding; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	negative regulation of cellular glucuronidation; heme catabolic process; cellular glucuronidation; xenobiotic glucuronidation; metabolism; negative regulation of glucuronosyltransferase activity; negative regulation of fatty acid metabolic process; bilirubin conjugation; flavonoid glucuronidation;
	Sources:Amigo / QuickGO
Orthologs
	54657
	394433
	ENSG00000244474
	ENSMUSG00000089943
	P22310
	n/a
	NM_007120
	NM_201643
	NP_009051
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 1-4 is an enzyme that in humans is encoded by the UGT1A4 gene.^[5]^[6]^[7]

Template:PBB Summary It is the main enzyme responsible for glucuronidation of the anticonvulsant lamotrigine.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000244474 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000089943 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (Oct 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. PMID 1339448.
^ "Entrez Gene: UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4".
^ Sandson NB, Armstrong SC, Cozza KL (2005). "An overview of psychotropic drug-drug interactions". Psychosomatics. 46 (5): 464–94. doi:10.1176/appi.psy.46.5.464. PMID 16145193.

References

Further reading