Enovid
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Enovid (in the United States) or Enavid (in the United Kingdom) was the first combined oral contraceptive pill (COCP). Developed by G. D. Searle & Company, it was first made available in the U.S. in 1957. Initially Enovid was marketed only for the treatment of menstrual disorders. On May 9, 1960 the U.S. Food and Drug Administration approved an application to market it as a contraceptive.[1] Just a few months later, in 1961, it was approved as a contraceptive in the UK.[2]
Enovid was discontinued in 1988, along with other first-generation high-estrogen COCPs.[3][4] Enovid consisted of 150 ug of mestranol and 9.58 mg of norethynodrel.
[edit] References
- ^ Junod SW, Marks L (2002). "Women's trials: the approval of the first oral contraceptive pill in the United States and Great Britain" (PDF). J Hist Med Allied Sci 57 (2): 117–60. doi:10.1093/jhmas/57.2.117. PMID 11995593. http://jhmas.oxfordjournals.org/cgi/reprint/57/2/117.pdf.
- ^ "ANNOTATIONS". Br Med J 2 (5258): 1007–9. October 14, 1961. doi:10.1136/bmj.2.3490.1009. PMC 1970146. PMID 20789252. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1970146.
"Medical News". Br Med J 2 (5258): 1032. October 14, 1961. doi:10.1136/bmj.2.5258.1032. PMC 1970195. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1970195. - ^ Reuters News Service (1988-04-15). "Searle, 2 others to stop making high-estrogen pill". St. Louis Post-Dispatch: pp. 7D. http://nl.newsbank.com/nl-search/we/Archives?p_text_direct-0=0EB327685B9D39FF&p_field_direct-0=document_id. Retrieved 2009-08-29.
- ^ "High-estrogen 'pill' going off market". San Jose Mercury News. 1988-04-15. http://nl.newsbank.com/nl-search/we/Archives?p_text_direct-0=0EB72D898C02F468&p_field_direct-0=document_id. Retrieved 2009-08-29.
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