Mestranol/norethynodrel
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(Redirected from Enovid)
| Combination of | |
|---|---|
| Mestranol | Estrogen |
| Norethynodrel | Progestogen |
| Clinical data | |
| Trade names | Enavid, Enovid |
| Pregnancy cat. | ? |
| Legal status | Discontinued |
| Routes | Oral |
| Identifiers | |
| ATC code | G03FA09 |
| PubChem | CID 66444 |
The first combined oral contraceptive pill (COCP) was the combination mestranol and norethynodrel (INNs), sold as Enovid in the United States and as Enavid (in the United Kingdom). Developed by G. D. Searle & Company, it was first made available to US physicians for trial in patients in 1957. Initially Enovid was marketed only for the treatment of menstrual disorders. The U.S. Food and Drug Administration approved an application to market it as a contraceptive on 9 March 1961.[1][2] Just a few months later, in 1961, it was approved as a contraceptive in the UK.[3][4]
Enovid was discontinued in 1988, along with other first-generation high-estrogen COCPs.[5][6]
See also [edit]
References [edit]
- ^ "FDA Approved Drug Products". FDA.
- ^ Junod, S. W.; Marks, L (2002). "Women's trials: the approval of the first oral contraceptive pill in the United States and Great Britain" (PDF). Journal of the History of Medicine and Allied Sciences 57 (2): 117–60. doi:10.1093/jhmas/57.2.117. PMID 11995593.
- ^ "ANNOTATIONS". Br Med J 2 (5258): 1007–9. October 14, 1961. doi:10.1136/bmj.2.3490.1009. PMC 1970146. PMID 20789252.
- ^ "Medical News". Br Med J 2 (5258): 1032. 1961 October 14. doi:10.1136/bmj.2.5258.1032. PMC 1970195.
- ^ Reuters News Service (1988-04-15). "Searle, 2 others to stop making high-estrogen pill". St. Louis Post-Dispatch. pp. 7D. Retrieved 2009-08-29.
- ^ "High-estrogen 'pill' going off market". San Jose Mercury News. 1988-04-15. Retrieved 2009-08-29.
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