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Enovid first came in a bottle.
Combination of
Mestranol Estrogen
Norethynodrel Progestogen
Clinical data
Trade names Enavid, Enovid
Legal status
  • Discontinued
Routes Oral
ATC code G03FA09
PubChem CID 66444

The first combined oral contraceptive pill (COCP) was the combination mestranol and norethynodrel (INNs), sold as Enovid in the United States and as Enavid in the United Kingdom. Developed by G. D. Searle & Company, it was first approved on June 10, 1957 by the U.S. Food and Drug Administration for treatment of menstrual disorders. The FDA approved an additional indication for use as a contraceptive on June 23, 1960.[1][2] In 1961, it was approved as a contraceptive in the UK.[3][4]

Enovid was discontinued in the U.S. in 1988, along with other first-generation high-estrogen COCPs.[5][6]

See also[edit]


  1. ^ "FDA Approved Drug Products". FDA. 
  2. ^ Junod, S. W.; Marks, L (2002). "Women's trials: the approval of the first oral contraceptive pill in the United States and Great Britain" (PDF). Journal of the History of Medicine and Allied Sciences 57 (2): 117–60. doi:10.1093/jhmas/57.2.117. PMID 11995593. 
  3. ^ "ANNOTATIONS". Br Med J 2 (5258): 1007–9. October 14, 1961. doi:10.1136/bmj.2.3490.1009. PMC 1970146. PMID 20789252. 
  4. ^ "Medical News". Br Med J 2 (5258): 1032. October 14, 1961. doi:10.1136/bmj.2.5258.1032. PMC 1970195. 
  5. ^ Reuters News Service (1988-04-15). "Searle, 2 others to stop making high-estrogen pill". St. Louis Post-Dispatch. pp. 7D. Retrieved 2009-08-29. 
  6. ^ "High-estrogen 'pill' going off market". San Jose Mercury News. 1988-04-15. Retrieved 2009-08-29.