Zinc-activated ion channel: Difference between revisions
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{{Ligand-gated ion channels}} |
{{Ligand-gated ion channels}} |
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[[Category:Ion channels]] |
[[Category:Ion channels]] |
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==External links== |
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* {{cite web | url = http://www.iuphar-db.org/IC/ObjectDisplayForward?familyId=6&objectId=171 | title = IUPHAR-DB: ZAC > | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }} |
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Revision as of 16:02, 18 August 2009
Template:PBB Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought it exist in the rat or mouse genomes.[1]
ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.[1][2] The endogenous ligand for ZAC is Zn2+, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.[1]
References
- ^ a b c Davies PA, Wang W, Hales TG, Kirkness EF (2003). "A novel class of ligand-gated ion channel is activated by Zn2+". J Biol. Chem. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochem Biophys Res Commun. 335 (2): 227–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
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External links
- "IUPHAR-DB: ZAC >". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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