GABRQ

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GABRQ
Identifiers
AliasesGABRQ, THETA, gamma-aminobutyric acid type A receptor theta subunit
External IDsMGI: 1888498 HomoloGene: 10233 GeneCards: GABRQ
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GABRQ
Genomic location for GABRQ
BandXq28Start152,638,183 bp[1]
End152,657,534 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018558

NM_001290435
NM_020488

RefSeq (protein)

NP_061028

NP_001277364
NP_065234

Location (UCSC)Chr X: 152.64 – 152.66 MbChr X: 72.83 – 72.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit theta is a protein that in humans is encoded by theGABRQ gene.[5][6] The protein encoded by this gene is a subunit of the GABAA receptor.

The θ subunit has highest sequence similarity with the β1 subunit.[6] This subunit coassembles with:

  • α2, β1, and γ1[6]
  • α3 and β1[7]
  • α3, β1, and ε.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268089 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031344 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Sinkkonen ST, Hanna MC, Kirkness EF, Korpi ER (15 May 2000). "GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus". J. Neurosci. 20 (10): 3588–95. PMID 10804200. 
  6. ^ a b c Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ (August 1999). "θ, a novel γ-aminobutyric acid type A receptor subunit". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9891–6. doi:10.1073/pnas.96.17.9891. PMC 22306Freely accessible. PMID 10449790. 
  7. ^ a b Ranna M, Sinkkonen ST, Möykkynen T, Uusi-Oukari M, Korpi ER (2006). "Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes". BMC Pharmacol. 6: 1. doi:10.1186/1471-2210-6-1. PMC 1363348Freely accessible. PMID 16412217. 

Further reading[edit]

External links[edit]