Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1gene.
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. The gene consists of 21 exons and is alternatively spliced, producing transcript variants differing in the C-terminus. Although the sequence of exon 5 is identical in human and rat, the alternative exon 5 splicing in rat has yet to be demonstrated in human. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits.
Lin JW, Wyszynski M, Madhavan R, et al. (1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1.". J. Neurosci.18 (6): 2017–27. PMID9482789.
Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.". Neurotoxicology19 (4–5): 683–8. PMID9745929.
Adriani W, Felici A, Sargolini F, et al. (1999). "N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes". Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale123 (1–2): 52–9. doi:10.1007/s002210050544. PMID9835392.
Dingledine R, Borges K, Bowie D, Traynelis SF (1999). "The glutamate receptor ion channels". Pharmacol. Rev.51 (1): 7–61. PMID10049997.
Magnuson DS, Knudsen BE, Geiger JD, et al. (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity". Ann. Neurol.37 (3): 373–80. doi:10.1002/ana.410370314. PMID7695237.
Foldes RL, Rampersad V, Kamboj RK (1994). "Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits". Gene147 (2): 303–4. doi:10.1016/0378-1119(94)90089-2. PMID7926821.
Sheng M, Cummings J, Roldan LA, et al. (1994). "Changing subunit composition of heteromeric NMDA receptors during development of rat cortex". Nature368 (6467): 144–7. doi:10.1038/368144a0. PMID8139656.
Tingley WG, Roche KW, Thompson AK, Huganir RL (1993). "Regulation of NMDA receptor phosphorylation by alternative splicing of the C-terminal domain". Nature364 (6432): 70–3. doi:10.1038/364070a0. PMID8316301.
Foldes RL, Rampersad V, Kamboj RK (1993). "Cloning and sequence analysis of cDNAs encoding human hippocampus N-methyl-D-aspartate receptor subunits: evidence for alternative RNA splicing". Gene131 (2): 293–8. doi:10.1016/0378-1119(93)90309-Q. PMID8406025.
Collins C, Duff C, Duncan AM, et al. (1993). "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and chromosome 8, respectively". Genomics17 (1): 237–9. doi:10.1006/geno.1993.1311. PMID8406459.
Lannuzel A, Lledo PM, Lamghitnia HO, et al. (1996). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons". Eur. J. Neurosci.7 (11): 2285–93. doi:10.1111/j.1460-9568.1995.tb00649.x. PMID8563977.
Corasaniti MT, Melino G, Navarra M, et al. (1996). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase". Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration4 (3): 315–21. doi:10.1016/1055-8330(95)90021-7. PMID8581564.