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Protein-coding gene in the species Homo sapiens
Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene .[ 5] [ 6] gems of Cajal bodies .
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies ), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[ 6]
Gem-associated protein 7 has been shown to interact with SMN1 [ 5] [ 7] Gem-associated protein 6 .[ 5] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000142252 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044709 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b c Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . The Journal of Biological Chemistry . 277 (35): 31957–31962. doi :10.1074/jbc.M203478200 PMID 12065586 . ^ a b "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7" .^ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . The Journal of Biological Chemistry . 277 (9): 7540–7545. doi :10.1074/jbc.M110141200 PMID 11748230 . ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex" . The Journal of Biological Chemistry . 281 (48): 37009–37016. doi :10.1074/jbc.M607505200 PMID 17023415 . Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome" . Cell . 122 (6): 957–968. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . S2CID 8235923 . Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization" . Human Molecular Genetics . 14 (20): 3099–3111. doi :10.1093/hmg/ddi343 PMID 16159890 .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Gem-associated protein 7
