UGT2B10

UGT2B10
Identifiers
Aliases	UGT2B10, UDPGT2B10, UDP glucuronosyltransferase family 2 member B10
External IDs	OMIM: 600070; MGI: 2140962; HomoloGene: 117389; GeneCards: UGT2B10; OMA:UGT2B10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,832,023 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,054,796 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; testicle; ; gallbladder; ; rectum; ; mucosa of transverse colon; ; islet of Langerhans; ; kidney; ; renal cortex; ; left testis;
	Top expressed in
	left lobe of liver; ; pyloric antrum; ; mucous cell of stomach; ; left colon; ; jejunum; ; duodenum; ; migratory enteric neural crest cell; ; epithelium of stomach; ; ileum; ; gallbladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; hexosyltransferase activity; glucuronosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; endoplasmic reticulum; membrane;
Biological process	metabolism; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	7365
	100727
	ENSG00000275190; ENSG00000109181
	ENSMUSG00000029260
	P36537
	n/a
	NM_001290091; NM_001075; NM_001144767
	NM_153598
	NP_001066; NP_001138239; NP_001277020
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B10 is an enzyme that in humans is encoded by the UGT2B10 gene.^[5]^[6]

References

^ ^a ^b ^c ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029260 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (Aug 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochem Biophys Res Commun. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.
^ "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".

Chen G, Dellinger RW, Gallagher CJ, et al. (2008). "Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines". Pharmacogenet. Genomics. 18 (3): 181–91. doi:10.1097/FPC.0b013e3282f4dbdd. PMID 18300939.
Chen G, Blevins-Primeau AS, Dellinger RW, et al. (2007). "Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism". Cancer Res. 67 (19): 9024–9. doi:10.1158/0008-5472.CAN-07-2245. PMID 17909004.
Kaivosaari S, Toivonen P, Hesse LM, et al. (2007). "Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10". Mol. Pharmacol. 72 (3): 761–8. doi:10.1124/mol.107.037093. PMID 17576790.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi:10.1074/jbc.M002180200. PMID 10748067.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999). "Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus". Biochem. J. 338 (2): 489–98. doi:10.1042/0264-6021:3380489. PMC 1220077. PMID 10024527.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000109181 GRCh38: Ensembl release 89: ENSG00000275190, ENSG00000109181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029260 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8333863-5] Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI (Aug 1993). "cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily". Biochem Biophys Res Commun. 194 (1): 496–503. doi:10.1006/bbrc.1993.1847. PMID 8333863.

[entrez-6] "Entrez Gene: UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10".

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References

Further reading