ADAMTS3

ADAMTS3
Identifiers
Aliases	ADAMTS3, ADAMTS-4, ADAM metallopeptidase with thrombospondin type 1 motif 3, HKLLS3
External IDs	OMIM: 605011; MGI: 3045353; HomoloGene: 8596; GeneCards: ADAMTS3; OMA:ADAMTS3 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	72,569,221 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,031,193 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; cartilage tissue; ; periodontal fiber; ; parietal pleura; ; germinal epithelium; ; tibia; ; testicle; ; caput epididymis; ; secondary oocyte; ; left uterine tube;
	Top expressed in
	neural layer of retina; ; superior frontal gyrus; ; zygote; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; ventricular zone; ; embryo; ; tail of embryo; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; zinc ion binding; endopeptidase activity; metal ion binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; metalloendopeptidase activity;
Cellular component	extracellular region; extracellular exosome; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	vascular endothelial growth factor production; collagen fibril organization; protein processing; proteolysis; collagen biosynthetic process; positive regulation of vascular endothelial growth factor signaling pathway; collagen catabolic process; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	9508
	330119
	ENSG00000156140
	ENSMUSG00000043635
	O15072
	n/a
	NM_014243
	NM_001081401; NM_177872
	NP_055058
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

A disintegrin and metalloproteinase with thrombospondin motifs 3 is an enzyme that in humans is encoded by the ADAMTS3 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156140 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043635 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461.
^ "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3".

External links

The MEROPS online database for peptidases and their inhibitors: M12.220
Human ADAMTS3 genome location and ADAMTS3 gene details page in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156140 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043635 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10094461-5] Tang BL, Hong W (Apr 1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461.

[entrez-6] "Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3".

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v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

References

Further reading

External links