ADAM 17 endopeptidase

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ADAM 17 endopeptidase
Identifiers
EC number 3.4.24.86
CAS number 151769-16-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

ADAM 17 endopeptidase (EC 3.4.24.86, tumor necrosis factor alpha-converting enzyme, TACE) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains

This enzyme belongs to the peptidase family M12.

References[edit]

  1. ^ Black, R.A. (2002). "Tumor necrosis factor-α converting enzyme. Int. J". Biochem. Cell Biol. 34: 1–5. doi:10.1016/S1357-2725(01)00097-8. PMID 11733179. 

External links[edit]