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ADK (gene)

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ADK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesADK, Adk, 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, Ak, adenosine kinase
External IDsOMIM: 102750; MGI: 87930; HomoloGene: 4891; GeneCards: ADK; OMA:ADK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243041
NM_134079

RefSeq (protein)

NP_001114
NP_001189378
NP_001189379
NP_006712

NP_001229970
NP_598840

Location (UCSC)Chr 10: 74.15 – 74.71 MbChr 14: 21.1 – 21.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.[5][6]

Function

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This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156110Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039197Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS (Mar 1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases". Proc Natl Acad Sci U S A. 93 (3): 1232–7. Bibcode:1996PNAS...93.1232S. doi:10.1073/pnas.93.3.1232. PMC 40062. PMID 8577746.
  6. ^ a b "Entrez Gene: ADK adenosine kinase".
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Further reading

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