FUT8

FUT8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DE0
Identifiers
Aliases	FUT8, fucosyltransferase 8, CDGF, CDGF1
External IDs	OMIM: 602589; MGI: 1858901; HomoloGene: 9650; GeneCards: FUT8; OMA:FUT8 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	65,744,121 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	77,523,112 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; olfactory bulb; ; testicle; ; trigeminal ganglion; ; inferior ganglion of vagus nerve; ; pylorus; ; ventricular zone; ; C1 segment; ; subthalamic nucleus; ; Achilles tendon;
	Top expressed in
	seminal vesicula; ; sciatic nerve; ; olfactory epithelium; ; left colon; ; epithelium of stomach; ; crypt of lieberkuhn of small intestine; ; optic nerve; ; lobe of cerebellum; ; olfactory tubercle; ; cerebellar vermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; SH3 domain binding; glycoprotein 6-alpha-L-fucosyltransferase activity; alpha-(1->6)-fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane; Golgi cisterna membrane; extracellular exosome; cytosol;
Biological process	GDP-L-fucose metabolic process; regulation of cellular response to oxidative stress; N-glycan fucosylation; N-glycan processing; in utero embryonic development; respiratory gaseous exchange by respiratory system; protein glycosylation; oligosaccharide biosynthetic process; regulation of gene expression; integrin-mediated signaling pathway; protein N-linked glycosylation; transforming growth factor beta receptor signaling pathway; cell migration; L-fucose catabolic process; receptor metabolic process; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	2530
	53618
	ENSG00000033170
	ENSMUSG00000021065
	Q9BYC5
	Q9WTS2
NM_004480; NM_178154; NM_178155; NM_178156; NM_178157;
	NM_001371533; NM_001371534; NM_001371536
	NM_001252614; NM_001252615; NM_001252616; NM_016893
NP_004471; NP_835368; NP_835369; NP_001358462; NP_001358463;
	NP_001358465
	NP_001239543; NP_001239544; NP_001239545; NP_058589
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000033170 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021065 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Costache M, Apoil PA, Cailleau A, Elmgren A, Larson G, Henry S, Blancher A, Iordachescu D, Oriol R, Mollicone R (Dec 1997). "Evolution of fucosyltransferase genes in vertebrates". J Biol Chem. 272 (47): 29721–8. doi:10.1074/jbc.272.47.29721. PMID 9368041.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)".

References

Further reading