Fallypride

Fallypride (¹⁸F)
Clinical data
Pregnancy; category	N/A;
ATC code	none;
Legal status
Legal status	Research compound;
Identifiers
	IUPAC name 5-(3-18F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide;
PubChem CID	10021692;
ChemSpider	8197265;
CompTox Dashboard (EPA)	DTXSID30937173 ;
Chemical and physical data
Formula	C20H29FN2O3
Molar mass	364.454263 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=CC(=C1OC)C(=O)NC[C@@H]2CCCN2CC=C)CCCF;
	InChI InChI=1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1; Key:OABRYNHZQBZDMG-INIZCTEOSA-N;

Fallypride is a high affinity dopamine D2/D3 receptor antagonist used in medical research,^[1] usually in the form of fallypride (¹⁸F) as a positron emission tomography (PET) radiotracer in human studies.^[2]^[3]

References

^ Mukherjee, J; Yang, Z. Y.; Das, M. K.; Brown, T (1995). "Fluorinated benzamide neuroleptics--III. Development of (S)-N-(1-allyl-2-pyrrolidinyl)methyl-5-(3-18Ffluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear Medicine and Biology. 22 (3): 283–96. PMID 7627142.
^ Mukherjee, J; Christian, B. T.; Dunigan, K. A.; Shi, B; Narayanan, T. K.; Satter, M; Mantil, J (2002). "Brain imaging of 18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse. 46 (3): 170–88. doi:10.1002/syn.10128. PMID 12325044.
^ Rieck, R. W.; Ansari, M. S.; Whetsell Jr, W. O.; Deutch, A. Y.; Kessler, R. M. (2004). "Distribution of dopamine D2-like receptors in the human thalamus: Autoradiographic and PET studies". Neuropsychopharmacology. 29 (2): 362–72. doi:10.1038/sj.npp.1300336. PMID 14627996.