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Glycoprotein-fucosylgalactoside a-N-acetylgalactosaminyltransferase

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glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
Identifiers
EC no.2.4.1.40
CAS no.9067-69-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.40) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl- (1,2)]-D-galactose

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-galactosamine and glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose, whereas its 3 products are UDP, [[glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-]], and [[(1,2)]-D-galactose]].

This enzyme belongs to the family of transferases, specifically those glycosyltransferases hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-ga lactose 3-N-acetyl-D-galactosaminyltransferase. Other names in common use include A-transferase, histo-blood group A glycosyltransferase, (Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase), UDP-GalNAc:Fucalpha1→2Galalpha1→3-N-acetylgalactosaminyltransferase, alpha-3-N-acetylgalactosaminyltransferase, blood-group substance alpha-acetyltransferase, blood-group substance A-dependent acetylgalactosaminyltransferase, fucosylgalactose acetylgalactosaminyltransferase, histo-blood group A acetylgalactosaminyltransferase, histo-blood group A transferase, UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose, and 3-N-acetyl-D-galactosaminyltransferase. This enzyme participates in 3 metabolic pathways: the lactoseries and neolactoseries of glycosphingolipid biosynthesis, as well as the biosynthesis of glycan structures.

Structural studies

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As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1LZ0, 1LZI, 1R7T, 1R7V, 1R7Y, 1R81, 1WSZ, 1WT0, 1WT1, 1WT2, 1WT3, 1XZ6, 1ZHJ, 1ZI1, 1ZI3, 1ZI4, 1ZI5, 1ZJO, and 2A8W.

References

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  • Kobata A, Grollman EF, Ginsburg V (1968). "An enzymic basis for blood type A in humans". Arch. Biochem. Biophys. 124 (1): 609–12. doi:10.1016/0003-9861(68)90373-1. PMID 5661629.
  • Takeya A, Hosomi O, Ishiura M (March 1990). "Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene". J. Biochem. 107 (3). Tokyo: 360–8. doi:10.1093/oxfordjournals.jbchem.a123051. PMID 2341371.
  • Yates AD, Feeney J, Donald AS, Watkins WM (1984). "Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase". Carbohydr. Res. 130 (1): 251–60. doi:10.1016/0008-6215(84)85283-0. PMID 6434182.