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HDAC1

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HDAC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDsOMIM: 601241; MGI: 108086; HomoloGene: 68426; GeneCards: HDAC1; OMA:HDAC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3065

433759

Ensembl

ENSG00000116478

ENSMUSG00000028800

UniProt

Q13547

O09106

RefSeq (mRNA)

NM_004964

NM_008228

RefSeq (protein)

NP_004955

NP_032254

Location (UCSC)Chr 1: 32.29 – 32.33 MbChr 4: 129.41 – 129.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[5]

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[6]

Model organisms

Model organisms have been used in the study of HDAC1 function. A conditional knockout mouse line, called Hdac1tm1a(EUCOMM)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[13][14][15] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty five tests were carried out and two phenotypes were reported. A reduced number of homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.[9]

Interactions

HDAC1 has been shown to interact with:

See also

References

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Further reading

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