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HEPPS (buffer)

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This is an old revision of this page, as edited by Ammarpad (talk | contribs) at 09:08, 3 April 2018 (Ammarpad moved page HEPPS (molecule) to HEPPS (buffer) without leaving a redirect: Requested by 空 at WP:RM/TR: Uniformity (like other Good's buffers, like CHES (buffer) or CAPS (buffer)). Currently, "HEPPS (buffer)" is a redirect toward "HEPPS (molecule)", it should be reversed, but I can't do it 'cause there's two lines in the history of HEPPS (molecule). Thanks.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

HEPPS
HEPPS
Names
IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
HEPPS, EPPS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.036.528 Edit this at Wikidata
  • InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) checkY
    Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N checkY
  • InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
    Key: OWXMKDGYPWMGEB-UHFFFAOYAP
  • O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
C9H20N2O4S
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.[1]

Research on mice with Alzheimers disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[2][3][4]

References

  1. ^ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry. 5 (2): 467–77. PMID 5942950.
  2. ^ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. Retrieved 14 December 2015. {{cite web}}: Italic or bold markup not allowed in: |publisher= (help)
  3. ^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
  4. ^ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. Retrieved December 10, 2015.

See also


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