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HEPPS (buffer)

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HEPPS
HEPPS
Names
IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
HEPPS, EPPS
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.036.528 Edit this at Wikidata
  • InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) checkY
    Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N checkY
  • InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)
    Key: OWXMKDGYPWMGEB-UHFFFAOYAP
  • O=S(=O)(O)CCCN1CCN(CCO)CC1
Properties
C9H20N2O4S
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

HEPPS or EPPS are the common names for the compound 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic acid. It is used as a buffering agent in biology and biochemistry. The pKa of HEPPS is 8.00. Research on mice with Alzheimers disease-like [[Amyloid beta ]] plaques has shown that the EPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[1][2]

References

  1. ^ "Small Molecule Breaks Up Amyloid Aggregates In Mice | Chemical & Engineering News". cen.acs.org. Retrieved 14 December 2015.
  2. ^ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997. {{cite journal}}: |access-date= requires |url= (help)

See also

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