Horrilysin
| Horrilysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.47 | ||||||||
| CAS no. | 84056-81-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Horrilysin (EC 3.4.24.47, Crotalus horridus metalloendopeptidase, hemorrhagic proteinase IV, Crotalus horridus horridus venom hemorrhagic proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
- Cleavage of only the single bond Ala14-Leu in the insulin B chain, Ser12-Leu in the A chain, and Ile-Gly, Pro-Ala, and Ser-Trp in melittin
This endopeptidase is present in the venom of the timber rattlesnake (Crotalus horridus horridus)
References
- ^ Civello, D.J.; Duong, H.L.; Geren, C.R. (1983). "Isolation and characterization of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22: 749–755. doi:10.1021/bi00273a007. PMID 6340728.
- ^ Civello, D.J.; Moran, J.B.; Geren, C.R. (1983). "Substrate specificity of a hemorrhagic proteinase from timber rattlesnake venom". Biochemistry. 22: 755–762. doi:10.1021/bi00273a008. PMID 6340729.
External links
- Horrilysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)