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N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase

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N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase
Identifiers
EC no.2.4.1.289
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289, WbbL) is an enzyme with systematic name dTDP-6-deoxy-beta-L-mannose:N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol 3-alpha-L-rhamnosyltransferase.[1][2] This enzyme catalyses the following chemical reaction

dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol dTDP + alpha-L-rhamnopyranosyl-(1->3)-N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol

This enzyme requires Mn2+ or Mg2+.

References

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  1. ^ Mills JA, Motichka K, Jucker M, Wu HP, Uhlik BC, Stern RJ, Scherman MS, Vissa VD, Pan F, Kundu M, Ma YF, McNeil M (October 2004). "Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability". The Journal of Biological Chemistry. 279 (42): 43540–6. doi:10.1074/jbc.M407782200. PMID 15294902.
  2. ^ Grzegorzewicz AE, Ma Y, Jones V, Crick D, Liav A, McNeil MR (December 2008). "Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL". Microbiology. 154 (Pt 12): 3724–30. doi:10.1099/mic.0.2008/023366-0. PMC 2717732. PMID 19047740.
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