N-acylsphingosine galactosyltransferase

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N-acylsphingosine galactosyltransferase
Identifiers
EC number2.4.1.47
CAS number37277-56-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acylsphingosine galactosyltransferase (EC 2.4.1.47) is an enzyme that catalyzes the chemical reaction

UDP-galactose + N-acylsphingosine UDP + D-galactosylceramide

Thus, the two substrates of this enzyme are UDP-galactose and N-acylsphingosine, whereas its two products are UDP and D-galactosylceramide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acylsphingosine D-galactosyltransferase. Other names in common use include UDP galactose-N-acylsphingosine galactosyltransferase, and uridine diphosphogalactose-acylsphingosine galactosyltransferase. This enzyme participates in sphingolipid metabolism.

References[edit]

  • Fujino Y, Nakano M (1969). "Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose". Biochem. J. 113 (3): 573&ndash, 5. PMC 1184705. PMID 5807218.