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Russellysin

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Russellysin
Identifiers
EC no.3.4.24.58
CAS no.79393-92-3
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Russellysin (EC 3.4.24.58, Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, metalloproteinase RVV-x, Vipera russelli proteinase, Russell's viper blood coagulation factor X activator, RVV-V) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B chain

This enzyme is present in the venom of Russell's viper (Vipera russelli).

References

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  1. ^ Furie BC, Furie B (1976). "Coagulant protein of Russell's viper venom". Part B: Proteolytic Enzymes. Methods in Enzymology. Vol. 45. pp. 191–205. doi:10.1016/s0076-6879(76)45019-x. ISBN 978-0-12-181945-3. PMID 1011991.
  2. ^ Lindquist PA, Fujikawa K, Davie EW (March 1978). "Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom". The Journal of Biological Chemistry. 253 (6): 1902–9. doi:10.1016/S0021-9258(19)62334-3. PMID 632245.
  3. ^ Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S (July 1992). "Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains". The Journal of Biological Chemistry. 267 (20): 14109–17. doi:10.1016/S0021-9258(19)49685-3. PMID 1629211.
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