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EC number3.4.24.58
CAS number79393-92-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum

Russellysin (EC, Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, metalloproteinase RVV-x, Vipera russelli proteinase, Russell's viper blood coagulation factor X activator, RVV-V) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B chain

This enzyme is present in the venom of Russell's viper (Vipera russelli).


  1. ^ Furie BC, Furie B (1976). "Coagulant protein of Russell's viper venom". Methods in Enzymology. 45: 191–205. doi:10.1016/s0076-6879(76)45019-x. PMID 1011991.
  2. ^ Lindquist PA, Fujikawa K, Davie EW (March 1978). "Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecedent) and a protease from Russell's viper venom". The Journal of Biological Chemistry. 253 (6): 1902–9. PMID 632245.
  3. ^ Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S (July 1992). "Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains". The Journal of Biological Chemistry. 267 (20): 14109–17. PMID 1629211.

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