Valter Longo

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Valter D. Longo
Born (1967-10-09) October 9, 1967 (age 49)
Genoa, Italy
Nationality Italian American
Fields Cell biology
Biogerontology
Institutions USC Davis School of Gerontology
Alma mater University of California, Los Angeles
Doctoral advisor Joan Valentine

Valter D. Longo (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his studies on the role of starvation and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute.

Career[edit]

Originally from Genoa, Italy, Valter Longo attended the University of North Texas[1] majoring in Biochemistry.

In 1992 he joined the laboratory of "calorie restriction" pioneer Roy Walford at UCLA where he studied calorie restriction and aging of the immune system. He completed his PhD work in Biochemistry studying antioxidant enzymes and anti-aging genes under Joan Valentine at UCLA in 1997 and his postdoctoral training in the neurobiology of Alzheimer's Disease under Caleb Finch at the University of Southern California. Since 1997 he has been a faculty member at the USC Davis School of Gerontology and Ethel Percy Andrus Gerontology Center.

Longo is a member of the formation of USC's Biology of Aging program as well as the director of the USC Longevity Institute,[2] also launched the USC Davis School of Gerontology's first study-abroad program, a summer class in the nutrition and genetics of aging in Italy.[3]

In 2011, he was profiled on Through the Wormhole with Morgan Freeman for his longevity-related research.[4]

Fast Mimicking Diet[edit]

Longo is inventor of the Fasting Mimicking Diet, a type of periodic fasting diet.[5]

Honors[edit]

Potential conflicts of interest[edit]

Valter Longo is a founder of a L-Nutra Inc., a company that markets food supplements.[7] However he has stated that he receives no profit from this company, and his goal is to be able to distribute these products at as low cost as possible to patients.[8] He has declared to Italian TV to have donated his quota to charity organizations (Italia 1 channel, Le Iene, October 9, 2016).

Selected publications[edit]

  • "Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients"[9]
  • "Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy"[10]
  • "Fasting and cancer treatment in humans: A case series report"[11]
  • "Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression"[12]
  • "Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population"[13]

References[edit]

  1. ^ "Faculty Profile: Valter Longo". USC Davis School of Gerontology. Retrieved 21 March 2012. 
  2. ^ "USC Longevity Institute". USC. Retrieved 21 March 2012. 
  3. ^ Riggs, Jonathan. "Gerontology and Genoa’s Lifestyle". USC News. Retrieved 21 March 2012. 
  4. ^ "USC in the News". USC Media and Public Relations. Retrieved 21 March 2012. 
  5. ^ Cheng; et al. "Fasting-mimicking diet may reverse diabetes". ScienceDaily. ScienceDaily. Retrieved 12 May 2017. 
  6. ^ "Nathan W. Shock Memorial Lecture Award Winners". National Institute on Aging. Retrieved 21 March 2012. 
  7. ^ "L-Nutra Team". L-Nutra Inc. Retrieved 13 June 2016. 
  8. ^ "https://www.youtube.com/watch?v=d6PyyatqJSE".  External link in |title= (help);
  9. ^ Lee, C; VD Longo (25 April 2011). "Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients". Oncogene. 30 (30): 3305–16. PMID 21516129. doi:10.1038/onc.2011.91. Retrieved 26 April 2012. 
  10. ^ Lee, Changhan; Lizzia Raffaghello; Sebastian Brandhorst; Fernando M. Safdie; Giovanna Bianchi; Alejandro Martin-Montalvo; Vito Pistoia; Min Wei; Saewon Hwang; Annalisa Merlino; Laura Emionite; Rafael de Cabo; Valter D. Longo (8 February 2012). "Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy". Science Translational Medicine. 4 (124): 124ra27. PMID 22323820. doi:10.1126/scitranslmed.3003293. Retrieved 26 April 2012. 
  11. ^ Safdie, Fernando M.; Tanya Dorff; David Quinn; Luigi Fontana; Min Wei; Changhan Lee; Pinchas Cohen; Valter D. Longo (December 2009). "Fasting and cancer treatment in humans: A case series report". Aging. 1 (12). Retrieved 26 April 2012. 
  12. ^ Chia-Wei Cheng; Gregor B. Adams; Laura Perin; Min Wei; Xiaoying Zhou; Ben S. Lam; Stefano Da Sacco; Mario Mirisola; David I. Quinn; Tanya B. Dorff; John J. Kopchick; Valter D. Longo (July 2014). "Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression". Cell Stem Cell. 14 (6): 810–823. PMC 4102383Freely accessible. PMID 24905167. doi:10.1016/j.stem.2014.04.014. Retrieved 20 February 2015. 
  13. ^ Longo, Valter; Valter Longo; Morgan E. Levine; Jorge A. Suarez; Sebastian Brandhorst; Priya Balasubramanian; Chia-Wei Cheng; Federica Madia; Luigi Fontana; Mario G. Mirisola; Jaime Guevara-Aguirre; Junxiang Wan; Giuseppe Passarino; Brian K. Kennedy; Min Wei; Pinchas Cohen; Eileen M. Crimmins (4 March 2014). "Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population". Cell Metabolism. 19 (3): 407–417. PMC 3988204Freely accessible. PMID 24606898. doi:10.1016/j.cmet.2014.02.006. Retrieved 14 September 2015. 

External links[edit]