Zolantidine

Zolantidine
Clinical data
ATC code	None;
Identifiers
	IUPAC name N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,3-benzothiazol-2-amine;
CAS Number	104076-38-2;
PubChem CID	91769;
ChemSpider	82866;
UNII	M1108XAY01;
ChEMBL	ChEMBL419296;
CompTox Dashboard (EPA)	DTXSID6048460 ;
Chemical and physical data
Formula	C22H27N3OS
Molar mass	381.5 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n1c4ccccc4sc1NCCCOc2cc(ccc2)CN3CCCCC3;
	InChI InChI=1S/C22H27N3OS/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24); Key:KUBONGDXTUOOLM-UHFFFAOYSA-N;

Zolantidine is a brain-penetrating selective histamine H₂ receptor (HRH₂) antagonist developed by Smith, Kline & French, with the research code of SK&F 95282. It is a benzthiazole derivative with a 30-fold higher potency for H₂ receptors than other peripheral and central receptors.^[1]

References

^ Calcutt, CR; Ganellin, CR; Griffiths, R; Leigh, BK; Maguire, JP; Mitchell, RC; Mylek, ME; Parsons, ME; Smith, IR; Young, RC (January 1988). "Zolantidine (SK&F 95282) is a Potent Selective Brain-penetrating Histamine H₂-receptor Antagonist". British Journal of Pharmacology. 93 (1): 69–78. doi:10.1111/j.1476-5381.1988.tb11406.x. PMC 1853786. PMID 2894879.

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[1] Calcutt, CR; Ganellin, CR; Griffiths, R; Leigh, BK; Maguire, JP; Mitchell, RC; Mylek, ME; Parsons, ME; Smith, IR; Young, RC (January 1988). "Zolantidine (SK&F 95282) is a Potent Selective Brain-penetrating Histamine H₂-receptor Antagonist". British Journal of Pharmacology. 93 (1): 69–78. doi:10.1111/j.1476-5381.1988.tb11406.x. PMC 1853786. PMID 2894879.

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