ZK-93426: Difference between revisions
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'''ZK-93426''' (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the [[beta-carboline]] family. It acts as a weak partial [[inverse agonist]] of [[benzodiazepine receptor]]s,<ref> |
'''ZK-93426''' (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the [[beta-carboline]] family. It acts as a weak partial [[inverse agonist]] of [[benzodiazepine receptor]]s,<ref>{{cite journal | pmid = 15805647 }}</ref> meaning that it causes the opposite effects to the [[benzodiazepine]] class of drugs and has [[anxiogenic]] properties,<ref>{{cite journal | pmid = 3009709 }}</ref> although unlike most benzodiazepine antagonists it is not a [[convulsant]] and actually has weak anticonvulsant effects.<ref>{{cite journal | pmid = 6089247 }}</ref> In human tests it produced alertness, restlessness and feelings of apprehension, and reversed the effect of the benzodiazepine [[lormetazepam]].<ref>{{cite journal | pmid = 2890423 }}</ref><ref>{{cite journal | pmid = 2905500 }}</ref> It was also shown to produce [[nootropic]] effects<ref>{{cite journal | pmid = 3064085 }}</ref><ref>{{cite journal | pmid = 8867876 }}</ref> and increased release of [[acetylcholine]].<ref>{{cite journal | pmid = 1334777 }}</ref><ref>{{cite journal | pmid = 8298971 }}</ref> |
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==See also== |
==See also== |
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Revision as of 19:46, 14 November 2010
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| Names | |
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| IUPAC name
ethyl 5-isopropoxy-4-methyl-9H-β-carboline-3-carboxylate
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| Other names
ZK-93426; ethyl 4-methyl-5-propan-2-yloxy-9H-pyrido[5,4-b]indole-3-carboxylate
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C18H20N2O3 | |
| Molar mass | 314.336 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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ZK-93426 (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties,[2] although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects.[3] In human tests it produced alertness, restlessness and feelings of apprehension, and reversed the effect of the benzodiazepine lormetazepam.[4][5] It was also shown to produce nootropic effects[6][7] and increased release of acetylcholine.[8][9]
See also
References
- ^ . PMID 15805647.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 3009709.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 6089247.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 2890423.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 2905500.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 3064085.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 8867876.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 1334777.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help) - ^ . PMID 8298971.
{{cite journal}}: Cite journal requires|journal=(help); Missing or empty|title=(help)
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