SB-408,124

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SB-408,124
SB408124 structure.png
Systematic (IUPAC) name
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea
Clinical data
Legal status ?
Identifiers
CAS number 288150-92-5
ATC code ?
Chemical data
Formula C19H18F2N4O 
Mol. mass 356.368 g/mol
 YesY (what is this?)  (verify)

SB-408,124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX1, with around 70x selectivity for OX1 over OX2 receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334,867. It is used in scientific research into the function of orexinergic neurons in the body.[1][2]

References[edit]

  1. ^ Langmead, CJ; Jerman, JC; Brough, SJ; Scott, C; Porter, RA; Herdon, HJ (2004). "Characterisation of the binding of 3H-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor". British Journal of Pharmacology 141 (2): 340–6. doi:10.1038/sj.bjp.0705610. PMC 1574197. PMID 14691055. 
  2. ^ Peng, HY; Chang, HM; Chang, SY; Tung, KC; Lee, SD; Chou, D; Lai, CY; Chiu, CH et al. (2008). "Orexin-A modulates glutamatergic NMDA-dependent spinal reflex potentiation via inhibition of NR2B subunit". American journal of physiology. Endocrinology and metabolism 295 (1): E117–29. doi:10.1152/ajpendo.90243.2008. PMID 18477704.