Centalun

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Centalun
Centalun.svg
Systematic (IUPAC) name
2-methyl-1-phenylbut-3-yne-1,2-diol
Clinical data
Legal status
  • Unscheduled
Identifiers
CAS number 2033-94-5 YesY
ATC code None
PubChem CID 16252
ChemSpider 15421 N
Chemical data
Formula C11H12O2 
Mol. mass 176.212 g/mol
 N (what is this?)  (verify)

Centalun was developed by Boehringer Ingelheim in 1962[1] and is a psycholeptic drug with hypnotic and sedative effects, via allosteric agonism of the GABAA receptor.[2] It was previously used for sedation in medical procedures such as surgery,[3] orthopedics[4] and gynecology,[5] although it is no longer in clinical use. Despite its history of clinical use, centalun was never incorporated into the CSA and therefor remains unregulated as a drug of abuse.

References[edit]

  1. ^ BE Patent 618130
  2. ^ Janke, W.; Glathe, H. (1964). "Experimental Studies on the Psychic Effect of Sedatives Under Normal and Stress Conditions". Psychologische Forschung 27: 377–402. PMID 14233519.  edit
  3. ^ Monecke, K. (1964). "Pre- and Postoperative Use of Centalun in Surgery". Deutsches medizinisches Journal 15: 470–471. PMID 14238754.  edit
  4. ^ Bruckschen, E. (1964). "Sedative Therapy with Centalun in Orthopedics". Deutsches medizinisches Journal 15: 493–494. PMID 14243120.  edit
  5. ^ Gerlach, W.; Gerlach, E. (1964). "Experiences with Centalun in Obstetrical and Gynecological Patients". Medizinische Monatsschrift 18: 131–133. PMID 14193290.  edit