Hypocretin (orexin) receptor 1

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Hypocretin (orexin) receptor 1
Identifiers
Symbols HCRTR1 ; OX1R
External IDs OMIM602392 MGI2385650 HomoloGene37492 IUPHAR: OX1 ChEMBL: 5113 GeneCards: HCRTR1 Gene
RNA expression pattern
PBB GE HCRTR1 207619 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3061 230777
Ensembl ENSG00000121764 ENSMUSG00000028778
UniProt O43613 P58307
RefSeq (mRNA) NM_001525 NM_001163027
RefSeq (protein) NP_001516 NP_001156499
Location (UCSC) Chr 1:
31.62 – 31.63 Mb
Chr 4:
130.13 – 130.14 Mb
PubMed search [1] [2]

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.[1]

Function[edit]

The orexin 1 receptor (OX1), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[1]

Ligands[edit]

Agonists[edit]

Antagonists[edit]

Further information: Orexin antagonist

See also[edit]

References[edit]

External links[edit]

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.