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Skeletal formula of bromisoval
CAS number 496-67-3 YesY, 27109-49-5 R YesY
PubChem 2447, 146955 R, 735997 S
ChemSpider 2353 YesY, 129594 R YesY, 643139 S YesY
UNII 469GW8R486 YesY
EC number 207-825-7
KEGG D01391
MeSH Bromisovalum
ATC code N05CM03
Jmol-3D images Image 1
Image 2
Molecular formula C6H11BrN2O2
Molar mass 223.07 g mol−1
log P 1.057
Acidity (pKa) 10.536
Basicity (pKb) 3.461
Routes of
Related compounds
Related ureas Carbromal
Related compounds
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Bromisoval (INN; commonly known as bromvalerylurea) is a hypnotic and sedative discovered by Knoll in 1907 and patented in 1909.[1] It is marketed over the counter in Asia under various trade names (such as Brovarin[2]), usually in combination with non-steroidal anti-inflammatory drugs.

Chronic use of bromisoval has been associated with bromine poisoning.[3][4][5][6]

See also[edit]


  1. ^ US patent 914518, Saam, E., "Alpha-halogen-isovaleryl-urea and process of making the same", issued 1909-03-09, assigned to Knoll 
  2. ^ "Bromisoval". International. 
  3. ^ Hashida, H.; Honda, T.; Morimoto, H.; Aibara, Y. (2001). "市販鎮痛剤常用量の服用による慢性ブロム中毒の1例" [A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia] (pdf). Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics (in Japanese) 38 (5): 700–703. doi:10.3143/geriatrics.38.700. ISSN 0300-9173. PMID 11605223.  edit
  4. ^ Kawakami, T.; Takiyama, Y.; Yanaka, I.; Taguchi, T.; Tanaka, Y.; Nishizawa, M.; Nakano, I. (1998). "Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse" (pdf). Internal Medicine (Tokyo, Japan) 37 (9): 788–791. doi:10.2169/internalmedicine.37.788. PMID 9804091.  edit
  5. ^ Wang, Y. -T.; Yang, S. Y.; Wu, V. C.; Wu, K. D.; Fang, C. C. (2005). "Pseudohyperchloraemia due to bromvalerylurea abuse". Nephrology Dialysis Transplantation 20 (8): 1767–1768. doi:10.1093/ndt/gfh945. PMID 15972320.  edit
  6. ^ Arai, A.; Sato, M.; Hozumi, I.; Matsubara, N.; Tanaka, K.; Soma, Y.; Adachi, T.; Tsuji, S. (1997). "Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning" (pdf). Internal Medicine (Tokyo, Japan) 36 (10): 742–746. doi:10.2169/internalmedicine.36.742. PMID 9372340.  edit