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| section_title =
| section_title =
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of [[macrophage]]s through the formation of membrane pores permeable to large molecules. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.<ref>{{cite web | title = Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5027| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of [[macrophage]]s through the formation of membrane pores permeable to large molecules. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria.<ref>{{cite web | title = Entrez Gene: P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5027| accessdate = }}</ref>


In melanocytic cells P2RX7 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]]<ref name="pmid19067971">{{cite journal | author = Hoek KS | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | author-separator = , | author2 = Schlegel NC | author3 = Eichhoff OM | display-authors = 3 | last4 = Widmer | first4 = Daniel S. | last5 = Praetorius | first5 = Christian | last6 = Einarsson | first6 = Steingrimur O. | last7 = Valgeirsdottir | first7 = Sigridur | last8 = Bergsteinsdottir | first8 = Kristin | last9 = Schepsky | first9 = Alexander }}</ref>.
In melanocytic cells P2RX7 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | author = Hoek KS | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | author-separator = , | author2 = Schlegel NC | author3 = Eichhoff OM | display-authors = 3 | last4 = Widmer | first4 = Daniel S. | last5 = Praetorius | first5 = Christian | last6 = Einarsson | first6 = Steingrimur O. | last7 = Valgeirsdottir | first7 = Sigridur | last8 = Bergsteinsdottir | first8 = Kristin | last9 = Schepsky | first9 = Alexander }}</ref>
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==References==
==References==
{{reflist}}
{{Reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
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*{{cite journal | author= Gartland A, Hipskind RA, Gallagher JA, Bowler WB. |title= Expression of a P2X7 receptor by a subpopulation of human osteoblasts |journal= J Bone Miner Res . |volume= 16 |issue= 5 |pages= 846–56 |year= 2001 |pmid= 11341329 |doi=10.1359/jbmr.2001.16.5.846 }}
*{{cite journal | author= Gartland A, Hipskind RA, Gallagher JA, Bowler WB. |title= Expression of a P2X7 receptor by a subpopulation of human osteoblasts |journal= J Bone Miner Res . |volume= 16 |issue= 5 |pages= 846–56 |year= 2001 |pmid= 11341329 |doi=10.1359/jbmr.2001.16.5.846 }}
*{{cite journal | author= Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. |title= Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice |journal= Crit Rev Eukaryot Gene Expr. |volume=13 |issue= 2–4 |pages= 243–53 |year= 2003 |pmid= 14696971 |doi=10.1615/CritRevEukaryotGeneExpr.v13.i24.160 }}
*{{cite journal | author= Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. |title= Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice |journal= Crit Rev Eukaryot Gene Expr. |volume=13 |issue= 2–4 |pages= 243–53 |year= 2003 |pmid= 14696971 |doi=10.1615/CritRevEukaryotGeneExpr.v13.i24.160 }}
{{PBB_Further_reading
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| citations =
| citations =
*{{cite journal | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
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*{{cite journal | author=Wilson HL, Wilson SA, Surprenant A, North RA |title=Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34017–23 |year= 2002 |pmid= 12107182 |doi= 10.1074/jbc.M205120200 }}
*{{cite journal | author=Wilson HL, Wilson SA, Surprenant A, North RA |title=Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34017–23 |year= 2002 |pmid= 12107182 |doi= 10.1074/jbc.M205120200 }}
*{{cite journal | author=Atkinson L, Milligan CJ, Buckley NJ, Deuchars J |title=An ATP-gated ion channel at the cell nucleus |journal=Nature |volume=420 |issue= 6911 |pages= 42 |year= 2002 |pmid= 12422208 |doi= 10.1038/420042a }}
*{{cite journal | author=Atkinson L, Milligan CJ, Buckley NJ, Deuchars J |title=An ATP-gated ion channel at the cell nucleus |journal=Nature |volume=420 |issue= 6911 |pages= 42 |year= 2002 |pmid= 12422208 |doi= 10.1038/420042a }}
*{{cite journal | author=Budagian V |title=Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1549–60 |year= 2003 |pmid= 12424250 |doi= 10.1074/jbc.M206383200 | author-separator=, | author2=Bulanova E | author3=Brovko L | display-authors=3 | last4=Orinska | first4=Z | last5=Fayad | first5=R | last6=Paus | first6=R | last7=Bulfone-Paus | first7=S }}
*{{cite journal | author=Budagian V |title=Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kappa B |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1549–60 |year= 2003 |pmid= 12424250 |doi= 10.1074/jbc.M206383200 | author-separator=, | author2=Bulanova E | author3=Brovko L | display-authors=3 | last4=Orinska | first4=Z | last5=Fayad | first5=R | last6=Paus | first6=R | last7=Bulfone-Paus | first7=S }}{{Retracted paper}}
*{{cite journal | author=Sluyter R, Wiley JS |title=Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors |journal=Int. Immunol. |volume=14 |issue= 12 |pages= 1415–21 |year= 2003 |pmid= 12456589 |doi=10.1093/intimm/dxf111 }}
*{{cite journal | author=Sluyter R, Wiley JS |title=Extracellular adenosine 5'-triphosphate induces a loss of CD23 from human dendritic cells via activation of P2X7 receptors |journal=Int. Immunol. |volume=14 |issue= 12 |pages= 1415–21 |year= 2003 |pmid= 12456589 |doi=10.1093/intimm/dxf111 }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author-separator=, | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author-separator=, | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
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* {{MeshName|P2RX7+protein,+human}}
* {{MeshName|P2RX7+protein,+human}}


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[[Category:Ion channels]]


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[[Category:Ion channels]]


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Revision as of 22:19, 25 March 2012

Template:PBB P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene.[1][2]

Template:PBB Summary

Recruitment of pannexin

Activation of the P2RX7 receptor by ATP leads to recruitment of pannexin pores[3] which allow small molecules such as ATP to leak out of cells. This allows further activation of purinergic receptors and physiological responses such a spreading cytoplasmic waves of calcium[4]

See also

References

  1. ^ Rassendren F, Buell GN, Virginio C, Collo G, North RA, Surprenant A (1997). "The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA". J Biol Chem. 272 (9): 5482–6. doi:10.1074/jbc.272.9.5482. PMID 9038151. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Buell GN, Talabot F, Gos A, Lorenz J, Lai E, Morris MA, Antonarakis SE (1999). "Gene structure and chromosomal localization of the human P2X7 receptor". Receptors Channels. 5 (6): 347–54. PMID 9826911. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18596211, please use {{cite journal}} with |pmid=18596211 instead.
  4. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19763139, please use {{cite journal}} with |pmid=19763139 instead.

Further reading

  • Gartland A, Buckley KA, Hipskind RA, Bowler WB, Gallagher JA. (2003). "P2 receptors in bone--modulation of osteoclast formation and activity via P2X7 activation". Crit Rev Eukaryot Gene Expr. 13 (2–4): 237–42. doi:10.1615/CritRevEukaryotGeneExpr.v13.i24.150. PMID 14696970.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Gartland A, Buckley KA, Bowler WB, Gallagher JA. (2003). "Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro". Calcif Tissue Int. 72 (4): 361–9. doi:10.1007/s00223-002-2098-y. PMID 12874700.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G, Gallagher JA. (2001). "Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling". Bone. 28 (5): 507–12. doi:10.1016/S8756-3282(01)00430-6. PMID 11344050.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Gartland A, Hipskind RA, Gallagher JA, Bowler WB. (2001). "Expression of a P2X7 receptor by a subpopulation of human osteoblasts". J Bone Miner Res . 16 (5): 846–56. doi:10.1359/jbmr.2001.16.5.846. PMID 11341329.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB, Gallagher JA. (2003). "Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice". Crit Rev Eukaryot Gene Expr. 13 (2–4): 243–53. doi:10.1615/CritRevEukaryotGeneExpr.v13.i24.160. PMID 14696971.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Template:PBB Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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