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Ro 3-0422

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Ro 3-0422
Names
Preferred IUPAC name
3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate
Other names
3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
Identifiers
3D model (JSmol)
ChemSpider
  • CCOP(=O)(OCC)Oc1cc2ccccc2[n+](c1)C.COS(=O)(=O)[O-]
Properties
C15H22NO8PS
Molar mass 407.37 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Extremely toxic
Lethal dose or concentration (LD, LC):
20 μg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]

See also

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References

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  1. ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
  2. ^ Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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