Ro 3-0419

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Ro 3-0419
Ro 3-0419.svg
Names
IUPAC name
Diethyl 3-quinolinyl phosphate
Other names
3-(Diethoxyphosphinyloxy)-quinoline
Identifiers
3D model (JSmol)
ChemSpider
Properties
C13H16NO4P
Molar mass 281.248 g·mol−1
Hazards
Main hazards Highly toxic
Lethal dose or concentration (LD, LC):
1 mg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Ro 3-0419 is a highly toxic organophosphate acetylcholinesterase inhibitor. It's the neutral analog of Ro 3-0422. Although Ro 3-0419 is less potent than Ro 3-0422, it does not have a positively charged nitrogen atom, so it's able to cross the blood brain barrier to inhibit cholinesterases in the brain. The intravenous LD50 of Ro 3-0419 is 1 mg/kg in mice.[1]

See also[edit]

References[edit]

  1. ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.