From Wikipedia, the free encyclopedia
Structural maintenance of chromosomes protein 4 (SMC-4) also known as chromosome-associated polypeptide C (CAP-C) or XCAP-C homolog is a protein that in humans is encoded by the SMC4 gene .[ 5] [ 6] [ 7] SMC-4 is a core subunit of condensin I and II, large protein complexes involved in chromosome condensation.
References
^ a b c GRCh38: Ensembl release 89: ENSG00000113810 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034349 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Schmiesing JA, Ball AR Jr, Gregson HC, Alderton JM, Zhou S, Yokomori K (Nov 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics" . Proc Natl Acad Sci U S A . 95 (22): 12906–11. doi :10.1073/pnas.95.22.12906 . PMC 23650 . PMID 9789013 .
^ Nishiwaki T, Daigo Y, Kawasoe T, Nagasawa Y, Ishiguro H, Fujita M, Furukawa Y, Nakamura Y (Jun 1999). "Isolation and characterization of a human cDNA homologous to the Xenopus laevis XCAP-C gene belonging to the structural maintenance of chromosomes (SMC) family" . J Hum Genet . 44 (3): 197–202. doi :10.1007/s100380050142 . PMID 10319587 .
^ "Entrez Gene: SMC4 structural maintenance of chromosomes 4" .
Further reading
Hirano T (2002). "The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair" . Genes Dev . 16 (4): 399–414. doi :10.1101/gad.955102 . PMID 11850403 .
Ball Jr AR, Yokomori K (2001). "The structural maintenance of chromosomes (SMC) family of proteins in mammals". Chromosome Res . 9 (2): 85–96. doi :10.1023/A:1009287518015 . PMID 11321372 .
Ham MF, Takakuwa T, Rahadiani N, et al. (2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma". Cancer Sci . 98 (7): 1041–7. doi :10.1111/j.1349-7006.2007.00500.x . PMID 17488335 .
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6. doi :10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220 .
Geiman TM, Sankpal UT, Robertson AK, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery" . Nucleic Acids Res . 32 (9): 2716–29. doi :10.1093/nar/gkh589 . PMC 419596 . PMID 15148359 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 . PMID 11230166 .
Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts" . J. Biol. Chem . 276 (8): 5417–20. doi :10.1074/jbc.C000873200 . PMID 11136719 .
Schmiesing JA, Gregson HC, Zhou S, Yokomori K (2000). "A Human Condensin Complex Containing hCAP-C–hCAP-E and CNAP1, a Homolog of Xenopus XCAP-D2, Colocalizes with Phosphorylated Histone H3 during the Early Stage of Mitotic Chromosome Condensation" . Mol. Cell. Biol . 20 (18): 6996–7006. doi :10.1128/MCB.20.18.6996-7006.2000 . PMC 88774 . PMID 10958694 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 .
External links
SMC4 human gene location in the UCSC Genome Browser .
SMC4 human gene details in the UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Structural maintenance of chromosomes protein 4 (SMC4)
PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Structural maintenance of chromosomes protein 4 (SMC4)