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SMC2

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SMC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDsOMIM: 605576; MGI: 106067; HomoloGene: 4705; GeneCards: SMC2; OMA:SMC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042550
NM_001042551
NM_001265602
NM_006444

NM_001301412
NM_008017

RefSeq (protein)

NP_001036015
NP_001036016
NP_001252531
NP_006435
NP_006435.2

NP_001288341
NP_032043

Location (UCSC)Chr 9: 104.09 – 104.14 MbChr 4: 52.44 – 52.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.[5][6]

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Interactions

SMC2 has been shown to interact with DNMT3B.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136824Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028312Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998). "Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics". Proceedings of the National Academy of Sciences of the United States of America. 95 (22): 12906–11. doi:10.1073/pnas.95.22.12906. PMC 23650. PMID 9789013.
  6. ^ "Entrez Gene: SMC2 structural maintenance of chromosomes 2".
  7. ^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Structural maintenance of chromosomes protein 2
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Structural maintenance of chromosomes protein 2