SMC2

SMC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4U4P
Identifiers
Aliases	SMC2, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
External IDs	OMIM: 605576; MGI: 106067; HomoloGene: 4705; GeneCards: SMC2; OMA:SMC2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q31.1 Start 104,094,260 bp End 104,141,419 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 B2|4 28.31 cM Start 52,439,243 bp End 52,488,260 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone testicle ganglionic eminence gonad Achilles tendon secondary oocyte sperm trabecular bone bone marrow bone marrow cells Top expressed in tail of embryo genital tubercle primitive streak abdominal wall maxillary prominence fetal liver hematopoietic progenitor cell mandibular prominence vas deferens dermis migratory enteric neural crest cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding protein heterodimerization activity ATP binding single-stranded DNA binding Cellular component cytoplasm cytosol chromosome nucleoplasm condensin complex nuclear chromosome nucleolus extracellular exosome condensed chromosome nucleus Biological process kinetochore organization meiotic chromosome condensation chromosome organization meiotic chromosome segregation cell division chromosome condensation cell cycle mitotic chromosome condensation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10592 14211 Ensembl ENSG00000136824 ENSMUSG00000028312 UniProt O95347 Q05D74 Q8CG48 RefSeq (mRNA) NM_001042550 NM_001042551 NM_001265602 NM_006444 NM_001301412 NM_008017 RefSeq (protein) NP_001036015 NP_001036016 NP_001252531 NP_006435 NP_006435.2 NP_001288341 NP_032043 Location (UCSC) Chr 9: 104.09 – 104.14 Mb Chr 4: 52.44 – 52.49 Mb PubMed search
Wikidata
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Structural maintenance of chromosomes protein 2 (SMC-2) also known as chromosome-associated protein E (CAP-E) is a protein that in humans is encoded by the SMC2 gene.

SMC-2 is a subunit of condensin I and II, large protein complexes involved in chromosome condensation.

Interactions

SMC2 has been shown to interact with DNMT3B.

Further reading

• Ham MF, Takakuwa T, Rahadiani N, Tresnasari K, Nakajima H, Aozasa K (Jul 2007). "Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma". Cancer Science. 98 (7): 1041–7. doi:10.1111/j.1349-7006.2007.00500.x. PMID 17488335.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
• Przewloka MR, Pardington PE, Yannone SM, Chen DJ, Cary RB (Feb 2003). "In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex". Molecular Biology of the Cell. 14 (2): 685–97. doi:10.1091/mbc.E01-11-0117. PMC 150001. PMID 12589063.
• Kimura K, Cuvier O, Hirano T (Feb 2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". The Journal of Biological Chemistry. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
• Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000). "A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation". Molecular and Cellular Biology. 20 (18): 6996–7006. doi:10.1128/MCB.20.18.6996-7006.2000. PMC 88774. PMID 10958694.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Structural maintenance of chromosomes protein 2
• PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Structural maintenance of chromosomes protein 2