Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33gene.[5][6]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (January 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–36. doi:10.1016/S0378-1119(01)00818-6. PMID11814695.
Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW (August 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID15347848. S2CID23971367.
Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (August 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID15387895.
Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE (July 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–3. doi:10.1513/pats.200603-026AW. PMID16799089.
Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP (July 2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–30. doi:10.1038/nature00878. PMID12110844. S2CID4424215.
Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID12535637.
Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA (October 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–22. doi:10.1016/s0091-6749(03)01939-0. PMID14564349.
Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–37. doi:10.1016/j.jmb.2003.10.037. PMID14659745.
Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (July 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID14742294.
Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE (May 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–65. doi:10.1164/rccm.200409-1251OC. PMID15709049.
Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (March 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–56. doi:10.1021/bi0476230. PMID15766253.
Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WE, Collins A, Custovic A, Holloway JW, John SL (July 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID15805180.
External links
The MEROPS online database for peptidases and their inhibitors: M12.244