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ADAM19 (ADisintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.[5]
Function
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.[5]
Adams MD, Kerlavage AR, Fields C, Venter JC (Jul 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nature Genetics. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID8358434.
Inoue D, Reid M, Lum L, Krätzschmar J, Weskamp G, Myung YM, Baron R, Blobel CP (Feb 1998). "Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells". The Journal of Biological Chemistry. 273 (7): 4180–7. doi:10.1074/jbc.273.7.4180. PMID9461614.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Hirohata S, Seldin MF, Apte SS (Nov 1998). "Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11". Genomics. 54 (1): 178–9. doi:10.1006/geno.1998.5544. PMID9806848.
Fritsche J, Moser M, Faust S, Peuker A, Büttner R, Andreesen R, Kreutz M (Jul 2000). "Molecular cloning and characterization of a human metalloprotease disintegrin--a novel marker for dendritic cell differentiation". Blood. 96 (2): 732–9. PMID10887142.
Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A (Mar 2001). "Roles of Meltrin beta /ADAM19 in the processing of neuregulin". The Journal of Biological Chemistry. 276 (12): 9352–8. doi:10.1074/jbc.M007913200. PMID11116142.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Wei P, Zhao YG, Zhuang L, Ruben S, Sang QX (Jan 2001). "Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta". Biochemical and Biophysical Research Communications. 280 (3): 744–55. doi:10.1006/bbrc.2000.4200. PMID11162584.
Zhao YG, Wei P, Sang QX (Nov 2001). "Inhibitory antibodies against endopeptidase activity of human adamalysin 19". Biochemical and Biophysical Research Communications. 289 (1): 288–94. doi:10.1006/bbrc.2001.5958. PMID11708814.
Kang T, Zhao YG, Pei D, Sucic JF, Sang QX (Jul 2002). "Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites". The Journal of Biological Chemistry. 277 (28): 25583–91. doi:10.1074/jbc.M203532200. PMID12006600.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kang T, Park HI, Suh Y, Zhao YG, Tschesche H, Sang QX (Dec 2002). "Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity". The Journal of Biological Chemistry. 277 (50): 48514–22. doi:10.1074/jbc.M208961200. PMID12393862.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (Sep 2002). "Screen and identification of proteins interacting with ADAM19 cytoplasmic tail". Molecular Biology Reports. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID12463424.
Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA (May 2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". The Journal of Biological Chemistry. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID12615925.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Chesneau V, Becherer JD, Zheng Y, Erdjument-Bromage H, Tempst P, Blobel CP (Jun 2003). "Catalytic properties of ADAM19". The Journal of Biological Chemistry. 278 (25): 22331–40. doi:10.1074/jbc.M302781200. PMID12682046.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kang T, Tschesche H, Amy Sang QX (Aug 2004). "Evidence for disulfide involvement in the regulation of intramolecular autolytic processing by human adamalysin19/ADAM19". Experimental Cell Research. 298 (1): 285–95. doi:10.1016/j.yexcr.2004.04.022. PMID15242783.
Ehrnsperger A, Rehli M, Thu-Hang P, Kreutz M (Jul 2005). "Epigenetic regulation of the dendritic cell-marker gene ADAM19". Biochemical and Biophysical Research Communications. 332 (2): 456–64. doi:10.1016/j.bbrc.2005.04.149. PMID15896713.
Melenhorst WB, van den Heuvel MC, Stegeman CA, van der Leij J, Huitema S, van den Berg A, van Goor H (Jul 2006). "Upregulation of ADAM19 in chronic allograft nephropathy". American Journal of Transplantation. 6 (7): 1673–81. doi:10.1111/j.1600-6143.2006.01384.x. PMID16827870.
Tanabe C, Hotoda N, Sasagawa N, Sehara-Fujisawa A, Maruyama K, Ishiura S (Jan 2007). "ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells". Biochemical and Biophysical Research Communications. 352 (1): 111–7. doi:10.1016/j.bbrc.2006.10.181. PMID17112471.