ADP-specific glucokinase

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ADP-specific glucokinase
Identifiers
EC number 2.7.1.147
CAS number 173585-07-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
ADPGK
Identifiers
Aliases ADPGK, 2610017G09Rik, ADP-GK, ADP-specific glucokinase, ADP-dependent glucokinase, ADP dependent glucokinase
External IDs MGI: 1919391 HomoloGene: 41739 GeneCards: ADPGK
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ADPGK
Genomic location for ADPGK
Band 15q24.1 Start 72,751,369 bp[1]
End 72,785,846 bp[1]
RNA expression pattern
PBB GE PNPLA6 203718 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031284

NM_028121

RefSeq (protein)

NP_112574

NP_082397

Location (UCSC) Chr 15: 72.75 – 72.79 Mb Chr 15: 59.29 – 59.32 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

ADP + D-glucose AMP + D-glucose 6-phosphate

Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, to be specific those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor.

In humans, the ADP-dependent glucokinase is encoded by the ADPGK gene.[5]

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159322 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025236 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ronimus RS, Morgan HW (Mar 2004). "Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase". Biochemical and Biophysical Research Communications. 315 (3): 652–8. doi:10.1016/j.bbrc.2004.01.103. PMID 14975750. 

External links[edit]

Further reading[edit]