Acrivastine
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 477241254
| IUPAC_name = (E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridin-2-yl}prop-2-enoic acid
| image = Acrivastine.svg
| tradename = | Drugs.com = International Drug Names | MedlinePlus = a682619 | pregnancy_AU = | pregnancy_US = B | legal_AU = | legal_CA = | legal_UK = GSL | legal_US = Rx-only | routes_of_administration = oral
| elimination_half-life = 1.5 hours | excretion = Renal
| CAS_number_Ref = 
| CAS_number = 87848-99-5
| ATC_prefix = R06
| ATC_suffix = AX18
| PubChem = 5284514
| DrugBank_Ref = 
| ChemSpiderID_Ref =
| ChemSpiderID = 4447574
| UNII_Ref =
| UNII = A20F9XAI7W
| KEGG_Ref =
| KEGG = D02760
| ChEMBL_Ref =
| ChEMBL = 1224
| ChEBI_Ref =
| ChEBI = 83168
| C=22 | H=24 | N=2 | O=2
| molecular_weight = 348.438 g/mol
| smiles = O=C(O)\C=C\c3nc(\C(=C\CN1CCCC1)c2ccc(cc2)C)ccc3
| StdInChI_Ref =
| StdInChI = 1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+
| StdInChIKey_Ref =
| StdInChIKey = PWACSDKDOHSSQD-IUTFFREVSA-N
}}
Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.
This non-sedating[verification needed] antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK. It is available as an over-the-counter medicine in the UK, and is available with or without pseudoephedrine under the Benadryl brand.
In the U.S., acrivastine is the active ingredient in the Semprex brand. Semprex-D also contains the decongestant pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals.[1]
Comparisons with other popular antihistamines
Unlike cetirizine or loratadine, for which the standard dose is one tablet per day, a single acrivastine tablet may be taken up to three times a day.[2] It is not to be taken by over 65s, pregnant women, or people with compromised liver or kidney function.
References
- ^ SEMPREX-D - acrivastine and pseudoephedrine hydrochloride capsule U.S. National Library of Medicine, National Institutes of Health, May 2008
- ^ "Benadryl Allergy Relief". electronic Medicines Compendium (eMC). 2014. Retrieved 4 July 2014.
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