Belotecan

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Belotecan
Belotecan.svg
Systematic (IUPAC) name
(4S)-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Identifiers
CAS Number 256411-32-2
ATC code None
PubChem CID 6456014
ChemSpider 4958253 YesY
UNII 27Z82M2G1N YesY
ChEMBL CHEMBL2107315
Chemical data
Formula C25H27N3O4
Molar mass 433.50 g/mol
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Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.