Zorubicin

Zorubicin
Clinical data
Trade names	rubidazon, rubidazone
Routes of; administration	i.v.
ATC code	L01DB05 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name (E)-N'-(1-((2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-2-yl)ethylidene)benzohydrazide;
CAS Number	54083-22-6;
PubChem CID	9595290;
DrugBank	DB11618 ;
ChemSpider	7869436;
UNII	V25F9362OP;
CompTox Dashboard (EPA)	DTXSID4043852 ;
Chemical and physical data
Formula	C34H35N3O10
Molar mass	645.665 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1=C(C(C4=C(C=CC=C4OC)C3=O)=O)C3=C(O)C2=C1[C@@H](O[C@]5([H])O[C@@H](C)[C@@H](O)[C@@H](N)C5)C[C@@](/[C@@](C)=N/NC(C6=CC=CC=C6)=O)(O)C2;
	InChI InChI=1S/C34H35N3O10/c1-15-28(38)20(35)12-23(46-15)47-22-14-34(44,16(2)36-37-33(43)17-8-5-4-6-9-17)13-19-25(22)32(42)27-26(30(19)40)29(39)18-10-7-11-21(45-3)24(18)31(27)41/h4-11,15,20,22-23,28,38,40,42,44H,12-14,35H2,1-3H3,(H,37,43)/b36-16+/t15-,20-,22-,23-,28+,34-/m0/s1; Key:FBTUMDXHSRTGRV-ALTNURHMSA-N;
	(verify)

Zorubicin (INN) is a benzoyl hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA; it as well interacts with topoisomerase II and inhibits DNA polymerases and therefore is used to treat cancer. ^[1]

References

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