Pirarubicin

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Pirarubicin
Pirarubicin.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
Synonyms (9S)-7-[(2R,4S,5S,6S)-4-amino-6-methyl-5-[(2R)-oxan-2-yl]oxyoxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C32H37NO12
Molar mass 627.63 g/mol
3D model (Jmol)
Melting point 188 to 192 °C (370 to 378 °F) (decomposes)
 NYesY (what is this?)  (verify)

Pirarubicin (INN) is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines.