Cellulose synthase (GDP-forming)

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cellulose synthase (GDP-forming)
EC no.
CAS no.9027-18-3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a cellulose synthase (GDP-forming) (EC is an enzyme that catalyzes the chemical reaction

GDP-glucose + (1,4-beta-D-glucosyl)n GDP + (1,4-beta-D-glucosyl)n+1

Thus, the two substrates of this enzyme are GDP-glucose and (1,4-beta-D-glucosyl)n, whereas its two products are GDP and (1,4-beta-D-glucosyl)n+1.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase. Other names in common use include cellulose synthase (guanosine diphosphate-forming), cellulose synthetase, guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase, and guanosine diphosphoglucose-cellulose glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

As of August 2019, no proteins with this activity are known in the UniProt/NiceZYme or the gene ontology database.


  • Chambers J, Elbein AD (1970). "Biosynthesis of glucans in mung bean seedlings. Formation of beta-(1,4)-glucans from GDP-glucose and beta-(1,3)-glucans from UDP-glucose". Arch. Biochem. Biophys. 138 (2): 620–31. doi:10.1016/0003-9861(70)90389-9. PMID 4317490.
  • Flowers HM, Batra KK, Kemp J, Hassid WZ (1969). "Biosynthesis of cellulose in vitro from guanosine diphosphate D-glucose with enzymic preparations from Phaseolus aureus and Lupinus albus". J. Biol. Chem. 244 (18): 4969–74. PMID 5824571.