GABRB2

GABRB2
Identifiers
Aliases	GABRB2, gamma-aminobutyric acid type A receptor beta2 subunit, ICEE2, gamma-aminobutyric acid type A receptor subunit beta2, DEE92
External IDs	OMIM: 600232 MGI: 95620 HomoloGene: 7327 GeneCards: GABRB2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	161,549,044 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	42,519,855 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; postcentral gyrus; ; middle temporal gyrus; ; entorhinal cortex; ; external globus pallidus; ; superior frontal gyrus; ; pons; ; cerebellar cortex; ; cerebellar hemisphere;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; globus pallidus; ; cerebellar vermis; ; lateral hypothalamus; ; ventromedial nucleus; ; mammillary body; ; ventral tegmental area; ; olfactory tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inhibitory extracellular ligand-gated ion channel activity; ion channel activity; GABA receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; GABA-gated chloride ion channel activity;
Cellular component	integral component of membrane; cytosol; GABA-A receptor complex; postsynaptic membrane; membrane; plasma membrane; integral component of plasma membrane; synapse; chloride channel complex; cell junction; GABA receptor complex; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; neuron projection; GABA-ergic synapse; integral component of postsynaptic specialization membrane;
Biological process	gamma-aminobutyric acid signaling pathway; negative regulation of neuron apoptotic process; chemical synaptic transmission; cochlea development; regulation of neuron apoptotic process; neuron development; chloride transmembrane transport; synaptic transmission, GABAergic; sensory perception of sound; ion transport; inner ear receptor cell development; chloride transport; innervation; negative regulation of neuron death; cellular response to histamine; transport; signal transduction; ion transmembrane transport; regulation of membrane potential; nervous system process; regulation of postsynaptic membrane potential; inhibitory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	2561
	14401
	ENSG00000145864
	ENSMUSG00000007653
	P47870
	P63137
	NM_000813; NM_021911; NM_001371727
	NM_008070; NM_001347314; NM_001362646; NM_001362647; NM_001362649
	NP_000804; NP_068711; NP_001358656
	NP_001334243; NP_032096; NP_001349575; NP_001349576; NP_001349578
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit beta-2 is a protein that in humans is encoded by the GABRB2 gene.^[5]^[6]

Template:PBB Summary

Interactions

GABRB2 has been shown to interact with TRAK2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145864 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007653 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics. 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879.
^ "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2".
^ Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33). United States: 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

External links

GABRB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:PBB Controls

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145864 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007653 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851879-5] Russek SJ, Farb DH (Mar 1995). "Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform". Genomics. 23 (3): 528–33. doi:10.1006/geno.1994.1539. PMID 7851879.

[entrez-6] "Entrez Gene: GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2".

[pmid12034717-7] Beck, Mike; Brickley Kieran; Wilkinson Helen L; Sharma Seema; Smith Miriam; Chazot Paul L; Pollard Simon; Stephenson F Anne (Aug 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. 277 (33). United States: 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

GABRB2

Interactions

See also

References

Further reading

External links