Gem-associated protein 5

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GEMIN5
Identifiers
Aliases GEMIN5, GEMIN-5, gem nuclear organelle associated protein 5
External IDs MGI: 2449311 HomoloGene: 9155 GeneCards: 25929
RNA expression pattern
PBB GE GEMIN5 gnf1h01818 at tn.png

PBB GE GEMIN5 gnf1h07897 at tn.png

PBB GE GEMIN5 gnf1h07920 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015465
NM_001252156

NM_001166669
NM_001166670
NM_001166671
NM_172558

RefSeq (protein)

NP_001239085.1
NP_056280.2

NP_001160141.1
NP_001160142.1
NP_001160143.1
NP_766146.2

Location (UCSC) Chr 5: 154.89 – 154.94 Mb Chr 11: 58.12 – 58.17 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[1][2]

Function[edit]

Gem-associated protein 5 is part of a the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[2]

Interactions[edit]

GEMIN5 has been shown to interact with DDX20[1][3] and SMN1.[1]

References[edit]

  1. ^ a b c Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716. 
  2. ^ a b "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5". 
  3. ^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. 

Further reading[edit]