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Gem (nuclear organelle) associated protein 8
Symbols GEMIN8 ; FAM51A1
External IDs MGI3646920 HomoloGene9882 GeneCards: GEMIN8 Gene
Species Human Mouse
Entrez 54960 237221
Ensembl ENSG00000046647 ENSMUSG00000040621
UniProt Q9NWZ8 Q8BHE1
RefSeq (mRNA) NM_001042479 NM_146238
RefSeq (protein) NP_001035944 NP_666350
Location (UCSC) Chr X:
14.01 – 14.03 Mb
Chr X:
166.17 – 166.19 Mb
PubMed search [1] [2]

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.[1][2]


Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[1]


  1. ^ a b "Entrez Gene: gem (nuclear organelle) associated protein 8". 
  2. ^ Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (March 2006). "Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly". J. Biol. Chem. 281 (12): 8126–34. doi:10.1074/jbc.M512243200. PMID 16434402. 

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