GEMIN8

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GEMIN8
Identifiers
Aliases GEMIN8, FAM51A1, gem nuclear organelle associated protein 8
External IDs MGI: 2384300 HomoloGene: 9882 GeneCards: 54960
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042479
NM_001042480
NM_017856

NM_146238
NM_001310722
NM_001310724

RefSeq (protein)

NP_001035944.1
NP_001035945.1
NP_060326.1

NP_001297651.1
NP_001297653.1
NP_666350.2

Location (UCSC) Chr X: 14.01 – 14.03 Mb Chr X: 166.17 – 166.19 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.[3][4]

Function[edit]

Gemin-8 is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: gem (nuclear organelle) associated protein 8". 
  4. ^ Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, Rappsilber J, Pellizzoni L (March 2006). "Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly". J. Biol. Chem. 281 (12): 8126–34. doi:10.1074/jbc.M512243200. PMID 16434402. 

Further reading[edit]