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Mabuterol
Names
IUPAC name
(RS )-1-[4-Amino-3-chloro-5-(trifluoromethyl)phenyl]-2-(tert-butylamino)ethanol
Identifiers
ChEMBL
ChemSpider
MeSH
mabuterol
UNII
InChI=1S/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3
Y Key: JSJCTEKTBOKRST-UHFFFAOYSA-N
Y InChI=1/C13H18ClF3N2O/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7/h4-5,10,19-20H,6,18H2,1-3H3
Key: JSJCTEKTBOKRST-UHFFFAOYAW
Clc1cc(cc(c1N)C(F)(F)F)C(O)CNC(C)(C)C
Properties
C13 H18 ClF3 N2 O
Molar mass
310.74 g/mol
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Mabuterol is a selective β2 adrenoreceptor agonist .[ 1] [ 2]
References
^ Osada, E; Murai, T; Ishizaka, Y; Sanai, K (1984). "Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs". Arzneimittel-Forschung . 34 (11A): 1641–51. PMID 6152157 .
^ Akahane K, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S (July 1989). "Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog" . Br. J. Pharmacol . 97 (3): 709–16. doi :10.1111/j.1476-5381.1989.tb12007.x . PMC 1854580 . PMID 2474351 .
α1
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β