A-366,833

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A-366,833
A-366833 structure.png
Systematic (IUPAC) name
5-[(1R,5S)-3,6-diazabicyclo[3.2.0]hept-6-yl]pyridine-3-carbonitrile
Identifiers
CAS Number 370882-41-0 YesY
PubChem CID 9834234
ChemSpider 8009955 YesY
ChEMBL CHEMBL239931 YesY
Chemical data
Formula C11H12N4
Molar mass 200.239
Physical data
Melting point 101.4–102.9 °C (214.5–217.2 °F) [1]
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A-366,833 is a drug developed by Abbott, which acts as an agonist at neural nicotinic acetylcholine receptors selective for the α4β2 subtype, and has been researched for use as an analgesic, although it has not passed clinical trials.[2][3]

References[edit]

  1. ^ Ji, Jianguo; Schrimpf, Michael R.; Sippy, Kevin B.; Bunnelle, William H.; Li, Tao; Anderson, David J.; Faltynek, Connie; Surowy, Carol S.; Dyhring, Tino; Ahring, Philip K.; Meyer, Michael D. (November 2007). "Synthesis and Structure−Activity Relationship Studies of 3,6-Diazabicyclo[3.2.0]heptanes as Novel α4β2 Nicotinic Acetylcholine Receptor Selective Agonists". Journal of Medicinal Chemistry. 50 (22): 5493–5508. doi:10.1021/jm070755h. PMID 17929796. 
  2. ^ Ji, J.; Bunnelle, W.; Anderson, D.; Faltynek, C.; Dyhring, T.; Ahring, P.; Rueter, L.; Curzon, P.; Buckley, M.; Marsh, K. C.; Kempf-Grote, A.; Meyer, M. D. (2007). "A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo3.2.0-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models". Biochemical Pharmacology. 74 (8): 1253–1262. doi:10.1016/j.bcp.2007.08.010. PMID 17854775. 
  3. ^ Romanelli, M.; Gratteri, P.; Guandalini, L.; Martini, E.; Bonaccini, C.; Gualtieri, F. (2007). "Central nicotinic receptors: structure, function, ligands, and therapeutic potential". ChemMedChem. 2 (6): 746–767. doi:10.1002/cmdc.200600207. PMID 17295372. 

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