Balovaptan

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Balovaptan
Balovaptan.svg
Clinical data
SynonymsRG7314
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC22H24ClN5O
Molar mass409.92 g·mol−1
3D model (JSmol)

Balovaptan (INN; developmental code name RG7314), is a selective small molecule antagonist of the vasopressin V1A receptor which is under development by Roche for the treatment of autism.[1] As of February 2019, it is in phase III clinical trials for this indication.[2] On January 29, 2018, Roche announced that the US Food and Drug Administration (FDA) had granted Breakthrough Therapy Designation for balovaptan in individuals with autism spectrum disorder (ASD).[3] The FDA granted this based on the results of the VANILLA (Vasopressin ANtagonist to Improve sociaL communication in Autism) study.[3] Another study (aV1ation) is currently recruiting participants.[4]

See also[edit]

References[edit]

  1. ^ "Roche - Pipeline". 2014. Retrieved 2014-08-01.
  2. ^ A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders, at ClinicalTrials.gov; retrieved February 6, 2018
  3. ^ a b "FDA grants Breakthrough Therapy Designation for Roche's balovaptan in autism spectrum disorder". 2018-01-29. Retrieved 2018-02-06.
  4. ^ "Aviation Study". www.theaviationstudy.com. Retrieved 2019-02-07.

External links[edit]